Current research projects

  • Ligusticum grayi phytochemical analysis (collaborators: UNC)
  • Schisandra spp. ethnobotany and phytochemical analysis (collaborators: Emory University)
  • Actea spp. against breast cancer cells (collaborators: NIH)
  • Multicomponent pharmacodynamics and pharmacokinetics (collaborators: NIH)
  • Phytochemical activators for orphan nuclear receptors  

Past research papers and book chapters

published by Kevin Spelman, PhD, MCPP

1. The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads

J Chromatogr B Analyt Technol Biomed Life Sci

Mar 2014

Novel technique for ligand discovery in botanical extracts.

Singh N, Ravichandran S, Spelman K, Fugmann SD, Moaddel R.

2. Clinical utility of curcumin extract

Altern Ther Health Med 19(2):20-2

Asher G, Spelman K.

Mar-Apr 2013

3. Detection, characterization, and screening of heme-binding molecules by mass spectrometry for malaria drug discovery(Link)

Analytical Chemistry

April 2012

Novel technique for anti-plasmodium screening.

  • Muñoz-Durango K, Maciuk A, Harfouche A, Torijano-Gutiérrez S, Jullian JC, Quintin J, Spelman K, et al.

4. A review of medicinal plants that modulate nitric oxide activity.(Link)

Alt Med Studies


  • Borchard J, Mazzarella L, Spelman K.

5. Cannabinoid-Opioid Interaction in Chronic Pain.(Link)

Nat Med J

June 2012

Review/Commentary on Abrams clinical trial:

  • Spelman K.

6. Traditional herbal remedies that influence cell adhesion molecule activity.(Link)

Phytother Res 25(4):473-83

April 2011

  • Spelman K, Aldag R, Hamman A, Kwasnik EM, Mahendra MA, Obasi TM, Morse J, Williams EJ.

7. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening.(Link)

J Biol Chem 412(1):85-91


Novel screening technique for cannabinoid ligands and first report of cannabinoid ligands in Zanthoxylum.

  • Moaddel R, Rosenberg A, Spelman K, Frazier J, Frazier C, Nocerino S, Brizzi A, Mugnaini C, Wainer IW.

8. The influence of bitter, aromatic and pungent medicinal plants on gut function.(Link)

in Gastrointestinal and Liver Disease Nutrition Desk Reference, CRC


  • Snow J, Spelman K.

9. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity.(Link)

Phytother Res 25(7):1098-101.

July 2011

First published report of active constituents and different extractions of Spilanthes acmella against Plasmodium falciparum and P.  yoelii yoelii in vivo and in vitro.

  • Spelman K, Depoix D, McCray M, Mouray E.

10. The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. Angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum(Link)

Revista Brasileira de Farmacognosia (Brazilian Journal of Pharmacognosy)

June 2011

First report of anti-plasmodium activity from Zanthoxylum chiloperone.

  • Cebrian-Torrejon, G; Spelman, K; Leblanc, K; Munoz-Durango, K; Gutierrez, ST; FerreiraI, ME. et al.

11. Ecological Pharmacy: From Gaia to Pharmacology.(Link)

Fundamentals of Complementary and Alternative Medicine. Saunders.


12. The influence of traditional herbal formulas on cytokine activity(Link)

Toxicology 278(1):140-59.


  • Burns JJ, Zhao L, Taylor EW, Spelman K.

13. Role for PPARγ in IL-2 inhibition in T cells by Echinacea derived undeca-2E-ene-8,10-diynoic acid isobutylamide(Link)

Int Immunopharmacol 9(11):1260-4


First report of PPAR-g induced immune activity by an Echinacea alkylamide.

  • Spelman K, Iiams-Hauser K, Cech NB, Taylor EW, Smirnoff N, Wenner CA.

14. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day(Link)

J Altern Complement Med


First published human data demonstrating diuresis from Taraxacum officinalis.

  • Clare BA, Conroy RS, Spelman K.

15. Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS(Link)

J Pharm Biomed Anal


Tentative identification of novel alkylamides in Echinacea purpurea.

  • Spelman K, Wetschler MH, Cech NB.

16. A critical evaluation of drug interactions with Echinacea spp.(Link)

Mol Nutr Food Res


A realistic perspective of HDIs.

  • Freeman C, Spelman K.

17. Types of Interactions of Plant Metabolites –Synergistic Modes of Interactions(Link)

Recent Advances in Plant Biotechnology.


  • Kirakosyan A, Kaufmann P, Boik J, Seymour M, Spelman K.

18. Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity.(Link)

Planta Med

December 2006

Structure of a novel  human hepatic microsomal alkylamide metabolite published for the first time.

  • Cech NB, Tutor K, Doty BA, Spelman K, Sasagawa M, Raner GM, Wenner CA.

19. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators(Link)

Altern Med Rev

June 2006

One of the top cited papers for Alt Med Rev.

Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M.

20. Philosophy in Phytopharmacology: Ockham's Razor versus synergy(Link)

J Herb Pharmacother


Discussion of pharmacological paradigms and the occurrence of synergic activity in medicinal plant extractions.

21. National policy dialogue to advance integrated health care:  Finding common ground-Final report to the Whitehouse(Link)

Alt Ther Health Med


22. Folate and vitamin B12 status of adolescent girls in northern Nigeria(Link)

J Natl Med Assoc

July 2000

Report of cobolamin deficiency, rather than folate deficiency, association with neural tube defects.

  • VanderJagt DJ, Spelman K, Ambe J, Datta P, Blackwell W, Crossey M, Glew RH.